Always visit a doctor in real life if you have any concerns about your health. Several features of this site … Over one-half century later, controversy continues to reign. What brand of mg are you using? Without the wrinkles you'd swear I was under 30! Although there is no clear-cut explanation of what exactly constitutes a vitamin megadose, according to Harvard University Medical School, it is generally a vitamin intake many times higher than the recommended amount. In fact, it has expanded well beyond the usefulness of vitamin C in … Now, a little over 1 week in, I seem to experience all of my regular symptoms with possibly even greater intensity than before starting supplements. The aspects of sleep the questionnaire assesses are summarized in Figure 2. Give the supplement some time to work (I'm guessing your doc wants you to return in 3-4 months for a vitamin d level recheck? and therefore there is not enough UV photon power within the tissues. Vitamin D : Women going through menopause may benefit from supplements of Vitamin D, which increases absorption of dietary calcium. In the US they typically say anything under I think it’s 50 ng/mL is deficient. Is Vitamin D induced serotonin syndrome possible? You must log in or register to reply here. There isn't a quick fix for the fatigue/brain fog, it might take some ruling out first. Same goes for lymph nodes, they can swell just because your body met something that it's fighting. Please contact the moderators of this subreddit if you have any questions or concerns. You can get vitamin D from supplements, but very high doses can cause health problems. By posting, you are agreeing to our Terms of Use and understand that all information is taken at your own risk. Does liver from grain-fed animals contain vitamin A? Contrary to their expectations, … The cells sense the D3 chemical signal but the tissues do not have the photon energy or momentum. I know plenty of people who have been doing this for decades and are fine. Vitamin D3 tested at 20 ng/ml, so my Primary Care put me on a supplement for 50k IU ergocalciferol (D2), taken twice a week for a few months. What’s the reality? Vitamin D, daily low dose or infrequent high dose? This was in the summer too when I was outside a lot. So you're getting double that dose per week, for longer, and you're not deficient...? The absorbtion through the skin is around 10% if you rub it in good and dont wash it off. I reacted immediately, rubbed it off, and took a quick shower with a lot of soap to rub it off fully. I experienced a major surge in energy levels, positive emotion, mental clarity, and my aches seemed less pronounced- it was almost euphoric. Had Extreme Reaction To Milk And Vitamin D. Maybe Milk Alkali Syndrome. Vitamin D is formed in the body after sun exposure, and it is naturally present in a few foods. Controversy has surrounded mega dosing with vitamin C since Nobel Prize winner Linus Pauling advocated the practice in the 1950s. The one with 365 drops at 2000 IU? Also, I wouldn't consider a runny nose always meaning "slightly sick", it could be allergies. While I'm trying to improve my diet, I am also debating supplementing a multivitamin, D3, K2, and magnesium. It took me a long time to feel back to normal when I was deficient. For a better experience, please enable JavaScript in your browser before proceeding. Please hear me out... Why politicians and doctors keep ignoring the medical research on Vitamin D and Covid. I know that there are claims that mega doses of vitamin c can prevent or cure everything from cancer to pimples. I have written a number of commentaries and reviews on this subject over the last couple of years and a recent paper published in the Journal: Joint Bone Spine presents a very interesting take on mega supplementation to restore Vit D status. If it's not working after a few months and your levels are good, ask about possible underlying depression as a cause. Peter R Ebeling MD, FRACP. So I think you don't need to worry. Maybe that wasn't the right terminology. Interesting.. do you think the major positive effects I experienced were possibly all placebo? I'll also feel very slightly sick often, e.g., swollen lymph nodes or runny nose. Other considerations: How long have you been feeling like this? Outcome measures: Serum levels of calcium, creatinine, 25‐hydroxyvitamin D 3 (25OHD 3 ) and parathyroid hormone, as well as early morning 2‐hour urine calcium/creatinine excretion index. I'm pretty good at limiting sugar and processed stuff. ), See what your next level is and go from there. I thought the bottle dropper was in the vitamin D supplement, but it wasn't, so I dumped about a quarter of the Carlson vitamin D on my belly button by mistake. Vitamin D is said to help stave off fatigue, depression and even cancer. I’d just like to say as a smoker of about 6 years now, you probably smoked something that was laced, or the vitamin c boosted your high so much you had a trip, especially since you’re a beginner smoker. Might be something to consider asking about. Vitamin D competes with other fat-soluble vitamins, so excessive dosages can imbalance them. Vitamin d is a big deal for the immune system and feeling well in general, so hopefully once your levels come up you start feeling "better". Megadose vitamin C therapy – Orthomolecular.org expounds on the therapy and its safety record. From Rhoda Patrick: Interestingly, both too high and too low vitamin D levels cause the same premature aging phenotype in mice.13,14 This means that aging shows a U shaped curve when it comes to vitamin D levels meaning there is an optimal vitamin D concentration (a sweet spot) in … However, this study was done in a group of dialysis patients, so it’s unknown if vitamin D would have the same effect in healthy people. Hey Drinkers....The case for Vitamin-Enriched Alcohol, The efficacy of vitamin E in reducing non-alcoholic fatty liver disease, The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification, Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes, Vitamin D prevents cortisol-induced depression and...inflammation, Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury, Vitamin D Supplementation is Improving my Sleep, This B-Vitamin Can Raise Dopamine (Thiamine tetrahydrofurfuryl disulfide - TTFD). Perhaps you're an odd bird reacting to 100,000 iu. ! Vitamin d3 is absorbed twice as well as d2. ; Although studies have found that poor sleep and low vitamin D levels are associated, researchers have yet to identify the root cause of this association. Having a medical issue? Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures Javascript is currently disabled in your browser. I kind of doubt the supplements are causing you issues, to be honest. Vit D in supplement form can take months to increase your levels and you shouldn't feel any effects right away. But some experts argue that for people with healthy levels, supplements are not helpful. I have already taken pharmaceutical vials with 200000 IU orally several times (with some weeks in between however) and never had any issues or side effects from the single very high dose. Vitamin A excess has some bad side effects so for that I will stick with only the multivitamin and food sources. JavaScript is disabled. So even if you thoroughly rubbed in 100,000 iu, you'd absorb only around 10,000. I have not know high doses of D3 or D2 to deplete mag. even if you absorbed the total 180000 IU which is not true you should be okay as long as you're not overloaded with vitamin D already, maybe just stay off the D for a few weeks if you're worried. A typical multi-vitamin contains around 30 to 40 units. (If yes, maybe you need a sleep study, something to discuss with your doc). Has your doctor mentioned potential underlying depression as a reason for your fatigue/brain fog? RDA : 5 - 10 Mcg (200-400 IU) It seems 50,000 once a week is typical. Maybe a doctor knows something otherwise. Do you exercise? Generally speaking, a combo of low vitamin d along with things it can subsequently cause like depression, pain, fatigue, etc add up to a pretty crappy feeling overall. LifeGivingStore.com New Products List:Hydrogen Breathing MachineNutritional Yeast Flakes Natural Dessicated Thyroid, LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Shampoo & Body Bars - Shaving Supplies - Laboratory & Research Chemicals Organs & Glands - Negative Ion Generators. More than that? Yet are such high doses of the vitamin genuinely useful? Participants were included if they suffered from poor sleep, as assessed by the Pittsburg Sleep Quality Index (PSQI), a questionnaire that measures sleep quality and disturbances over the previous month. Fluorescent pee after b vitamin supp, Normal?! Vitamin B6 Increases Serotonin, Regardless of Serotonin Levels - PUBMED, Vitamin B12 Facilitates the Retroconversion of Estrogens into Androgens by Bacteria. All flaired medical professionals on this subreddit are verified by the mods. NAD - Maybe you can ask your doctor about your dosage. Click here for the Orthomolecular Medicine News Service archive.. Is vitamin K2 required when taking Vitamin D? Press J to jump to the feed. Poor sleep was defined as a total score of five or more, out of 21, on the PSQI questionnaire, with subsequent confi… Less? Unfortunately, these effects diminished quickly. I am a bot, and this action was performed automatically. Vitamin C Megadose – Why Large Doses Aren't So Large A vitamin C megadose is considered anything that is many times greater than the RDA (Recommended Daily Allowance) of about 90 mg. This study was a double-blind, randomized controlled trial on 93 people ages 20 to 50 years in a single hospital in Iran. Is Vitamin A (retinol Palmitate/acetate) Dangerous During Pregnency? So as our vitamin D level rises because we take the supplement orally we give our gut VDR's a falsely elevated signal. With 50k units weekly being the typical dose for vitamin d3 in a deficient patient, 50k units of d2 twice a week isn't too much. What do you mean by pronounced immune response? Please note that a response does not constitute a doctor-patient relationship. I would just ask the doc to switch it to d3 though. This changes optical signaling in the GALT and its T cells. Vitamin D toxicity is usually caused by large doses of vitamin D supplements — not by diet or sun exposure. Unaware of any studies of meg-doses of vitamin D There have been several indications that getting lots of vitamin D (> 20,000 IU daily) can cure some diseases Appears that Vitamin D can induce remission in recent Multiple Sclerosis 1,000 patients 20,000 IU to 140,000 IU daily It may not display this or other websites correctly. -By 'pronounced immune response', I meant that I generally feel very inflamed: achy, inflamed muscles, puffy face, atrocious brain fog, tired eyes + fatigue. Any thoughts on what this could be? “Extreme vitamin B12 – extra high dose!” This is how some manufacturers advertise their vitamin B12 products. I hope a physician who is qualified to speak on this comments, because that seems too high to me! I’ve had bad feelings like that happen to me when I first started smoking because I got so loaded and my body didn’t know how to take it. Sept. 6, 2005 (Stockholm, Sweden) -- When it come to heart health, megadoses of vitamin B may do more harm than good.. Vitamin D Supplementation During Winter: Effects On Stress Resilience. Can the high doses of Vitamin D deplete magnesium, etc.? Vitamin B12 is a healthy and vital vitamin, which benefits the body in many ways. 19/White male, 5'11, 150lbs, otherwise healthy, no drugs or alcohol, I've been experiencing very bad daytime fatigue / brain fog / body aches, pronounced immune responses, etc., so I got some labs done. What Is a Vitamin Megadose?. My mood improved from deeply depressed to okay, and suddenly felt less fatigued.I slept like a baby. Vitamin B12 Megadose – Is More Always Better? Cheap Vitamin C products, any contamination risk? I reacted immediately, rubbed it off, and took a quick shower with a lot of soap to rub it off fully. (vitamin D, magnesium, liver), Vitamin E succinate decreases melanoma size by 650% in vivo, Vitamin B1 in critically ill patients: needs and challenges. Interestingly, Vitamin D supplementation decreases klotho, which increases IQ and longevity . However...that is a crazy high dose for someone who isn't even deficient. Lots of nuts (almonds, pecans, walnuts), oats, apples, turkey, beef, broccoli, bread, almond milk, eggs, cheese, potatoes. The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource – click here for a free subscription. If you wiped it off quickly I wouldn't stress over it too much. Add that to the trainwreck of a year we've all experienced and it wouldn't surprise me you feel terrible. A megadose of vitamin D is 10 times the daily recommended amount, according to Jeffrey Blumberg, a vitamin expert at Tufts University. The first few days after supplementation, I felt amazing. Separating 31 participants into three groups, the researchers gave one group high doses of vitamin D and one group a lower dose of vitamin D, with the third group receiving a placebo. I’m actually not taking any mag supplements at the moment. Many Americans are deficient in vitamin D, which can impact all kinds of things including our sleep. Long version: This is tough because most of these things can be related to deficient vitamin d in some way, but some could be caused by other things. Hm, interesting. Vitamin D toxicity, also called hypervitaminosis D, is a rare but potentially serious condition that occurs when you have excessive amounts of vitamin D in your body. Vitamins, Minerals & Amino Acid Supplements, A Megadose Of Vitamin E 'slows Down' Alzheimer's, A very confusing month? Never use this subreddit as your first and final source of information regarding your question. A young Australian man who was critically ill with COVID-19 and suffering early stages of sepsis made a remarkable recovery after being given massive doses of vitamin C, according to his doctors. -Not checked in most recent labs, but I would guess it's not terrible, as I get good amounts of magnesium-rich foods. Interesting podcast on dangers of vitamin E supplementation, Cistanche more effective at decreasing lipid peroxidation and free radicals than Vitamin E and Caffeine, The efficacy of Vitamin K in the treatment of cancer. The dr put me on 80,000 iu vitamin d3 once a week for 8 weeks. If you can't wait that long, I'd call and ask if they have any other recommendations or ask about the possibility of depression being a source of the issues and see what they say. In combination with Calcium, Vitamin D is said to alleviate hot flashes, night sweats, leg cramps and other symptoms of menopause. When I was at 20 they gave me 2,000 IU per day. I thought the bottle dropper was in the vitamin D supplement, but it wasn't, so I dumped about a quarter of the Carlson vitamin D on my belly button by mistake. Vitamin K2's effect on Lunulae (fingernail crescents). Thank you for your submission. Press question mark to learn the rest of the keyboard shortcuts. Anyways, I tell people to find something USP verified to avoid that problem if you're going over the counter. Definitely good to know, thanks for the info! This post can be deleted, sorry for the bother. Corresponding Author. Ask a doctor or medical professional on Reddit! Our Beloved Family: I’m so proud to have been inducted as a Fellow into the Linus Pauling Institute, also known as the Institute of Orthomolecular Medicine. Do you sleep 8 hours? Professor Rinaldo Bellomo, director of Intensive Care at Melbourne’s Austin Health, said the 40-year-old’s health had started to deteriorate significantly from COVID-19, with the […] Your doc is starting with the normal path, he/she found your low vitamin d so that is to be fixed first and move along from there. It was sometime during that I slowly started feeling better. Megadose therapy for vitamin D deficiency. In the UK we would treat people with below 10 ng/mL with 50,000 IU vitamin D once a week for 6 weeks. When the vitamin D system is driven to excess, hypercalcemia results because of increased intestinal calcium absorption and by the induction of bone resorption. Such little amounts of vitamin C only prevent scurvy and lead us into a subclinical scurvy state. It’s still not enough to require 100,000 IU tho. How can Vitamin K2 MK-4 be Price's Activator X? Participants: Five men and 45 women (mean age 66.3 years) with vitamin D deficiency who were given a single therapeutic intramuscular injection of 600 000 IU (15 mg) cholecalciferol (vitamin D 3). TLDR: look at your sleep habits, exercise, continue to eat well, stay hydrated, take your vitamin d and do the repeat lab work I'm assuming your doctor ordered for a few months from now (he/she should have). How is your diet? Do you snore? I think my vit d measurement was 14 when I found out why I felt so bad. Interesting study claims Vitamin K2 should be classified as a hormone, The Ameliorating Effects Of Vitamin E On Hepatotoxicity Of Ecstasy, I’m Not Convinced Vitamin D Should Be Supplemented, 7-fold Higher COVID-19 Mortality In Vitamin D Deficient Subjects. Mega-dose supplements contain from 400 to 800 units or higher, which is turning out to be quite a high dose, according to the study. How is your sleep at night? Always inform your doctor of any changes, especially if you have parathyroid problems. I am sensitive to medicines and dosages that are fine for other people can often hit me hard. Edit: I just realised you're taking vitamin D2, so the dose might not be as crazy as I made out. -It's fine (I think). ... and my Ph.D. at Harvard University, and I have published over 250 scientific papers. But that’s exactly how many you’d have to eat to get the same amount of vitamin C contained in a single 1,000-milligram (mg) megadose tablet of vitamin C. The daily recommended dose for vitamin C is actually 75-120 mg, and although taking up to 2,000 mg can be safe, it is not recommended, especially because doing so consistently can result in side effects like an upset stomach and diarrhea. Usually it's more like weight loss supplements that do that though. Absolutely staves off viruses if done at the first sign. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS. This subreddit is for informal second opinions and casual information. Treating Illness with Megadose Vitamin C More Matters When it Comes to Preventing Illness Through Vitamin Supplements. Best of luck . Make sure you're eating with your vitamin d, it's fat soluble so taking it with a (healthy) high fat meal (not mcdonald's LOL) will help with absorption. That can help with energy, I know it seems like a catch 22 with the fatigue though. I've always believed that Vitamin D doses should be much higher than what doctors usually tell us, but I … Just lay off the d for a week if you want. Vitamin K2 and magnesium seem to be important modulators of this mineralization balance. Reading Time: 5 minutes Vitamin D supplementation, and what levels to use are common discussions amongst Nutritional Therapists. peter.ebeling@mh.org.au; While there was possibly some placebo effect, I definitely wasn't expecting that type of result in less than a week, so it seems like it must have been real. The mod team does their best to remove bad information, but we do not catch all of it. You are using an out of date browser. Thu., Nov. 1, 2018. How many of you have gotten Vitamin D injections? If you're in the us, anything sold as a "supplement" can have literally anything put in it, including illegal drugs, and cannot be removed from the market until it starts killing people. All other lab results normal (testosterone, thyroid, other vitamins, etc). Some sources would say you're low, but others wouldn't even say that. I tested negative recently for COVID, and this has been persistent for a few months. Vitamin C is being promoted on social media as a treatment for coronavirus. Yesterday I took 50,000UI of Vitamin D and suddenly felt great. I should also add I don't think your vitamin D levels are responsible for your symptoms in the first place, given how they're unremarkable. All I know is the above, and also that I have none of the problems so often seen in people my age, such as high blood pressure, diabetes, or anything else for that matter. Deputy Director, Department of Diabetes and Endocrinology; and Senior Principal Fellow and Associate Professor, Department of Medicine. Getting enough vitamin D is crucial for your overall health. Vitamin D Deficiency 19/White male, 5'11, 150lbs, otherwise healthy, no drugs or alcohol I've been experiencing very bad daytime fatigue / brain fog / body aches, pronounced immune responses, etc., so I got some labs done. What was your magnesium level? A&E Mega-dosing vitamin D: Doctor-prescribed 50,000 IU vitamin D may be right for some patients.