February 2015. Glucosamine side effects include headaches, diarrhea and drowsiness. In rare cases, use of glucosamine may cause such side effects as drowsiness, skin reactions, vomiting, headache, elevated blood pressure and heart rate, and palpitations. Ther Adv Musculoskelet Dis. Mild side effects include vomiting or abnormal feces production (either diarrhea or constipation). Other chondroitin side effects include heart palpitations, swollen ankles or eyelids. Is N-Acetylglucosamine the Best Form of Glucosamine? Regul Toxicol Pharmacol. Stop using chondroitin and glucosamine and … 2015;8(4):458-461. So far, research on the effects of glucosamine and chondroitin sulfate in osteoarthritis patients has produced conflicting results. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. However, there's some evidence that glucosamine and chondroitin sulfate may help alleviate pain, ease stiffness, reduce swelling, and improve function in people with osteoarthritis. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Although not all side effects are known, chondroitin and glucosamine is thought to be possibly safe when taken for up to 2 years. Caused by the breakdown of cartilage, people with osteoarthritis suffer from pain, joint damage and limited motion. Hathcock JN, Shao A. Glucosamine is a sugar that helps your body make cartilage while chondroitin helps to maintain flexibility. Meanwhile, chondroitin sulfate is purported to treat cataracts, dry eye syndrome, high cholesterol, and urinary tract infections. Arthritis Foundation. Glucosamine is generally a very safe supplement, but like any type of dietary supplement, you should always consider the risks before deciding on treatment. Chondroitin sulfate: MedlinePlus Supplements. Reported side effects include; stomach upset, gastrointestinal upset and skin rash , but these are infrequent and if they were to occur the supplement could be discontinued. Chondroitin sulfate is naturally present in the cartilage surrounding your joints. Black C1, Clar C, Henderson R, MacEachern C, McNamee P, Quayyum Z, Royle P, Thomas S. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. In general, glucosamine and chondroitin sulfate nutritional supplements appear to be quite safe. Constipation 5. 2007;24(7):573-80. Common side effects may include: nausea, diarrhea, constipation; stomach pain, gas, bloating; hair loss; or puffy eyelids. Chondroitin side effects may include nausea, hair loss, and diarrhea. The chondroitin sulfate found in dietary supplements is usually produced from animal sources, such as cow cartilage, and thus is not suitable for those with vegetarian or vegan diets. Can Wearing a Copper Bracelet Ease Arthritis Pain? Glucosamine supplements are often paired with chondroitin, which promote joint repair. The chondroitin sulfate found in dietary supplements is usually produced from animal sources, such as cow cartilage, and thus is not suitable for those with vegetarian or vegan diets. Skin reactions 7. Majority of arthritis supplements contain glucosamine and chondroiti… 2011;5:69-77. doi:10.2174/1874312901105010069, Henrotin Y, Mathy M, Sanchez C, Lambert C. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Risk assessment for glucosamine and chondroitin sulfate. The source of glucosamine is not required to be printed on the label, so it may require a phone call to the manufacturer. Your doctor can review the other medications you are taking and help you decide whether or not these arthritis supplements are right for you. Het kan zelfstandig worden gebruikt, maar het kan ook uitstekend met glucosamine worden gecombineerd. That's why it's so important to ensure that you're comfortable with the risk of glucosamine side effects. National Institutes of Health. 20 Supplements and Vitamins for Arthritis, The Health Benefits of Cetyl Myristoleate, Study: Glucosamine and Chondroitin May Offer Cardiovascular Benefits. Bruyere O, Reginster JY. Should You Take Osteo Bi-Flex for Your Joint Pain? Glucosamine and chondroitin are both found naturally in cartilage. Glucosamine sulfate: MedlinePlus Supplements. Sawitzke AD, Shi H, Finco MF, et al. Open Rheumatol J. Glucosamine and chondroitin seem to be, in safety studies that have been done in the United States, basically as safe as taking placebo. Other natural remedies that show promise in the treatment of osteoarthritis include white willow bark, Pycnogenol, avocado/soybean unsaponifiables, omega-3 fatty acids, and bromelain. While any associated side effects are generally mild, as with all medications and supplements, there are risks with their use. These were the second most popular dietary supplement after fish oil and other types of omega-3 fatty acids. There is some evidence both supplements can help control osteoarthritis by protecting against the breakdown of cartilage. They are sleep disturbances, drowsiness, headaches, upset stomach, skin reactions, sensitivity to the sun and hardening of the nails. 2009 Nov;13(52):1-148. Mild stomach pain and nausea are the two side effects most frequently caused by chondroitin sulfate. The current article gives a brief description of the possible side effects and allergies due to these supplements. Preliminary studies show glucosamine sulfate and chondroitin sulfate to be safe and well tolerated. Research on Glucosamine as a Arthritis Treatment Has Mixed Results, people with allergies to shellfish should avoid glucosamine, Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials, Crystalline glucosamine sulfate in the treatment of osteoarthritis: evidence of long-term cardiovascular safety from clinical trials, Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Cathy Wong is a nutritionist and wellness expert. Allergic Reaction to Glucosamine Their presence in joint tissues has led to the inclusion of them in joint health supplements to be … Is Glucosamine Effective for Treating Knee Osetoarthritis? If you stop taking NSAIDS or COX-2 inhibitors, the pain quickly comes back. Common side effects may include: nausea, diarrhea, constipation; stomach pain, gas, bloating; hair loss; or puffy eyelids. Other side effects: chondroitin may also occasionally cause stomach upsets. Glucosamine may also interact with certain medications used during chemotherapy. Mild stomach pain and nausea are the two side effects most frequently caused by chondroitin sulfate. Potentially serious side effects of the supplement include heart palpitations and swollen eyelids. Here are some of the other side effects most commonly associated with glucosamine:. There's some concern that the use of glucosamine may aggravate such conditions as asthma, diabetes, high blood pressure, and high cholesterol. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. J Orthop Surg Res. It is important to check with your doctor before starting any new treatments. Call your doctor for medical advice about side effects. When taken in appropriate amounts, glucosamine sulfate appears to be safe. This fact is surprising to many. Drugs Aging. Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles. It is also proven to relieve pain and treat osteoarthritis in the joints. Side Effects of Glucosamine and Chondroitin Sulfate, Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. We comply with the HONcode standard for trustworthy health information -. Chondroitin, on the other hand, enhances the shock-absorbing capacity of the cartilage and makes it more flexible. Oral use of glucosamine sulfate can cause: 1. Chondroitin is similar to glucosamine and also occurs naturally in joints. 2010 Aug;69(8):1459-64. Glucosamine is a type of supplement you take daily. These side effects are reported in a small portion of patients. Ann Rheum Dis. Of the available forms, glucosamine sulfate — with or without chondroitin — is likely the most effective. Since glucosamine may affect your blood sugar levels and interfere with blood sugar control during surgery, it's important to avoid the use of glucosamine for at least two weeks prior to undergoing a scheduled surgery. It should be noted that, like glucosamine and chondroitin sulfate, each of the above remedies is associated with a range of side effects. Available for Android and iOS devices. Although not all side effects are known, chondroitin and glucosamine is thought to be possibly safe when taken for up to 2 years. What the Science Says About Safety and Side Effects No serious side effects have been reported in large, well-conducted studies of people taking glucosamine, chondroitin, or both for up to 3 years. February 2015. You may report them to the FDA. Chondroitin sulfate may also trigger the following side effects:. Frankly speaking, the use of Glucosamine for diabetics will not have a negative impact on them. Glucosamine helps make your cartilage stronger and rigid. Glucosamine and chondroitin sulfate supplements are prescribed for individuals suffering from osteoarthritis. With glucosamine, there is a residual effect. J Med Life. It is important to be aware of these and to discuss the use of any supplement with your physician. Applies to chondroitin / glucosamine: oral capsule, oral kit, oral tablet. A number of glucosamine chondroitin study have revealed the effect of these components in the body. Australian Rheumatology Association and Arthritis Australia Statement regarding the use of glucosamine for the treatment of Osteoarthritis Recent media reports have raised concern over the use of … Glucosamine sulfate may also cause a short-term rise in both heart rate and blood pressure. Even if you stop taking it, you will still be protected for a period of time. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Taking glucosamine with food may help reduce the occurrence of digestive issues associated with glucosamine. Chondroïtine is een voedingssupplement dat vergelijkbaar is met glucosamine. Common side effects may include: Nausea; Diarrhea; Gastrointestinal upset. 2018;13(1):170. doi:10.1016/j.pcl.2011.10.018, Palma dos reis R, Giacovelli G, Girolami F, André R, Bonazzi A, Rovati LC. Chondroitin sulfate is naturally present in the cartilage surrounding your joints. aspirin, prednisone, ibuprofen, meloxicam, naproxen, Cymbalta, biotin, multivitamin, ascorbic acid, calcium / vitamin d. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Possible Risks and Side Effects Glucosamine supplements are … 2007 Feb;47(1):78-83. Mild gastrointestinal disturbance is the most common adverse effect. However, the NIH cautions that the safety of using glucosamine and/or chondroitin sulfate while pregnant or breastfeeding is unknown. Other adverse effects include headache, drowsiness, insomnia and skin reactions. Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy. Het is mogelijk deze stof aan te vullen door middel van een supplement. It is important to notify your healthcare provider immediately if you experience any possible side effects of glucosamine and chondroitin (however minor they may seem). Thank you, {{form.email}}, for signing up. Its still there, but your brain is numb to the pain due to the effects of the drugs. Zhu X, Sang L, Wu D, Rong J, Jiang L. Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. A compound found naturally in your body, glucosamine is also available in the shells of shrimp, lobsters, and other shellfish. Glucosamine and chondroitin sulfate may interact with a number of medicines, including blood-thinning drugs like Coumadin (warfarin), Plavix (clopidogrel), or Ticlid (ticlopidine) and supplements such as garlic, ginkgo, vitamin E, or red clover. Based on research findings, if you plan on using glucosamine and chondroitin, the dosing recommendation is glucosamine sulfate at 1,500 mg per day in combination with chondroitin sulfate at 800-1,200 mg per day. According to the National Institutes of Health (NIH), both glucosamine and chondroitin sulfate are likely safe for most adults. If you take warfarin or have blood sugar problems, make sure to talk to your doctor about the potential side effects if you are considering or taking glucosamine or chondroitin. Food Chem Toxicol. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 2010;2(6):335-48. doi:10.1177/1759720X10383076. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. NSAIDS and COX-2 inhibitors do nothing but cover up the pain. Crystalline glucosamine sulfate in the treatment of osteoarthritis: evidence of long-term cardiovascular safety from clinical trials. She helped co-author the first integrative geriatrics textbook, "Integrative Geriatric Medicine.". Chondroïtine is een stof die van nature in het menselijk lichaam geproduceerd wordt. Two popular dietary supplements, glucosamine sulfate and chondroitin sulfate, are often used as natural remedies for osteoarthritis. Stop using chondroitin and glucosamine and call your healthcare provider at once if you have: This is not a complete list of side effects and others may occur. The most common side effects occur that have been reported are gastrointestinal in nature, such as upset stomach, nausea, heartburn, and diarrhea. Can Graviola Help Fight Diabetes and Cancer? Anderson JW1, Nicolosi RJ, Borzelleca JF. In addition, always follow the instructions on the medication label. Rogoveanu OC, Streba CT, Vere CC, Petrescu L, Trăistaru R. Superior digestive tract side effects after prolonged treatment with NSAIDs in patients with osteoarthritis. Side effects of glucosamine chondroitin Supplements containing glucosamine and chondroitin may cause side effects, which if they occur, are usually gastrointestinal. The most common side effect of chondroitin, when it is consumed separately is hair loss. The use of chondroitin sulfate, meanwhile, may have harmful effects in people with asthma, blood clotting disorders, or prostate cancer. Since glucosamine supplements may be made from shellfish, people with allergies to shellfish should avoid glucosamine unless it has been confirmed that it is a non-shellfish source. This is not a complete list of side effects and others may occur. In spite of that fact, clinical studies have found that Glucosamine has no effect on … Common side effects may include: nausea, vomiting; diarrhea, constipation; or; heartburn. If you're currently taking medication, make sure to consult your physician before using glucosamine or chondroitin sulfate. However, glucosamine or chondroitin may interact with the anticoagulant (blood-thinning) drug warfarin (Coumadin). However, these chemicals are not devoid of side effects. 2005 Feb;43(2):187-201. Drowsiness 6. Glucosamine and Chondroitin for Osteoarthritis Pain. National Institutes of Health. Taking glucosamine and/or chondroitin sulfate with food seems to reduce the incidence of the above side effects. Do not take more of the supplements than is recommended. Although many dietary supplements contain glucosamine sourced from shellfish, some products contain synthetic forms of this compound. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Some side effects may not be reported. Read our, Medically reviewed by Anita C. Chandrasekaran, MD, MPH, Medically reviewed by Arno Kroner, DAOM, LAc, Medically reviewed by Jonathan Cluett, MD, Medically reviewed by Corinne Savides Happel, MD, Medically reviewed by Lana Butner, ND, LAc, Medically reviewed by Rochelle Collins, DO, Medically reviewed by Kashif J. Piracha, MD, The Health Benefits of Glycosaminoglycans. There is conflicting evidence suggesting that glucosamine, in doses used to treat osteoarthritis, may increase insulin and/or hemoglobin A1c (a test that measures how well blood sugar has been controlled during the previous three months) levels in people with diabetes or insulin resistance. Glucosamine Side Effects There are a number of possible side effects linked to glucosamine sulfate. Glucosamine Chondroitin Side Effects An estimated 27 million adults in the United States live with osteoarthritis—the most common type of arthritis, according to NIH's National Center for Complementary and Alternative Medicine. Chondroitin sulfate may also trigger the following side effects:3 1. constipation 2. diarrhea 3. hair loss 4. irregular heartbeat 5. swelling of the eyelids or … From a technical standpoint, Glucosamine is a type of sugar. Long-Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six-Year Followup Data From the Osteoarthritis Initiative Arthritis Care Res (Hoboken) . Follow all directions on the product label and package. Glucosamine when taken alone can give rise to mild but bothersome side effects. Diarrhea 4. The use of joint supplements for canine arthritis has increased exponentially in recent years, especially considering that many of the drugs prescribed for arthritis can cause unpleasant side effects if used long-term. While management of osteoarthritis is the most common use of glucosamine sulfate and chondroitin sulfate, there is some evidence each also aids in the treatment of a variety of conditions. For example, glucosamine is touted as a natural remedy for interstitial cystitis, temporomandibular joint disorder, and glaucoma. Heartburn 3. Nausea 2. It has also been seen to lessen the inflammation and promote improved joint function in general. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis. Epub 2006 Aug 30. Health Technol Assess. Glucosamine supplements are either produced synthetically or derived from the shells of shellfish, and should not precipitate allergic reactions in patients sensitive to shellfish.